Two sample MR report
HLA-DQB1_Interstitial Macrophages against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | -0.0685500 | 0.5049066 | 0.9044371 |
| Weighted median | 4 | -0.1034572 | 0.0248219 | 0.0000307 |
| Inverse variance weighted | 4 | -0.1032911 | 0.0210649 | 0.0000009 |
| Simple mode | 4 | -0.1067918 | 0.0343146 | 0.0527934 |
| Weighted mode | 4 | -0.1067283 | 0.0321667 | 0.0451225 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0420713 | 2 | 0.9791840 |
| Inverse variance weighted | 0.0468140 | 3 | 0.9973436 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0193257 | 0.2806234 | 0.9513614 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001591 | 0 | TRUE | 0.2363524 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
